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Skip to content O estudo genômico mais abrangente da sífilis até hoje mapeou o recente ressurgimento da doença em todo o mundo. A transmissão global da sífilis é generalizada, principalmente nos últimos 20 anos, de acordo com pesquisas publicadas na Nature Microbiology.
Pesquisadores da Escola de Higiene e Medicina Tropical de Londres (LSHTM), Instituto Wellcome Sanger, Agência de Segurança de Saúde do Reino Unido e seus colaboradores mapearam o recente ressurgimento da doença em todo o mundo. Eles encontraram amostras de sífilis quase idênticas entre 14 países, com a população global de sífilis composta por duas linhagens, SS14 e Nichols.
A análise detalhada dessas linhagens fornece informações importantes sobre a diversidade genética da sífilis, com implicações para o projeto de vacinas e resistência antimicrobiana.
A sífilis é uma das infecções sexualmente transmissíveis (IST) mais comuns em todo o mundo, com aproximadamente seis milhões de infecções a cada ano. Causado pela bactéria Treponema pallidum, é facilmente tratável, embora os sintomas possam desaparecer antes que o indivíduo perceba que está infectado ou possam nem aparecer. Se não tratada, a sífilis pode causar sérios problemas de saúde a longo prazo.
As infecções por sífilis que ocorrem durante a gravidez podem ser transmitidas à criança, causando sífilis congênita. Esta é a segunda principal causa de natimortalidade em todo o mundo e pode ter consequências graves no desenvolvimento de crianças a termo. Ela pode ser prevenida por meio de exames e tratamento precoces durante a gravidez. A sífilis congênita é mais comum em países sem esses programas de rastreamento.
Para este estudo – financiado pela Wellcome – pesquisadores do LSHTM e do Wellcome Sanger Institute coordenaram a coleta de 726 amostras de sífilis de 23 países. Isso incluiu áreas bem amostradas, como Estados Unidos e Europa Ocidental, bem como regiões mal amostradas, como Ásia Central, Austrália e África.
O Sanger Institute sequenciou o genoma de cada amostra e conduziu análises filogenéticas e de agrupamento para mapear a população global de sífilis.
Como as mudanças no DNA ocorrem em uma taxa conhecida e previsível ao longo do tempo, as relações ancestrais entre as diferentes sequências podem ser estabelecidas. A equipe descobriu que todas as amostras vieram de apenas duas linhagens profundamente ramificadas, Nichols e SS14. Ambas as linhagens estão circulando atualmente em 12 dos 23 países amostrados, e amostras quase idênticas estiveram presentes em 14 desses países.
A incidência da sífilis diminuiu durante as décadas de 1980 e 1990, em parte devido a práticas sexuais mais seguras na esteira da epidemia de HIV / AIDS. Mas nas últimas décadas a sífilis aumentou novamente, aumentando em mais de 300% em alguns países desde 2010. A sífilis afeta desproporcionalmente homens que fazem sexo com homens (HSH) em alguns países – por exemplo, 90% dos casos de sífilis no Reino Unido em 2017 foram entre HSH .
A Dra. Helen Fifer, autora sênior do artigo da Agência de Segurança de Saúde do Reino Unido (UKHSA), disse: "A explosão de casos de sífilis nas últimas décadas é extremamente preocupante. É uma infecção sexualmente transmissível que pode facilmente passar despercebida, com um grande proporção de casos diagnosticados na fase latente entre homens que fazem sexo com homens (HSH) nos últimos anos. Um aumento da sífilis entre heterossexuais também é preocupante devido ao risco de sífilis congênita. Qualquer pessoa que tenha relações sexuais com parceiros novos ou casuais deve usar um preservativo e faça o teste – as DSTs podem trazer consequências graves para a saúde dos indivíduos e para a saúde dos seus atuais ou futuros parceiros sexuais. "
O estudo é um recurso valioso para a compreensão da diversidade genética do T. pallidum que terá implicações para o desenho de vacinas e resistência aos medicamentos. Muitas das amostras sequenciadas eram resistentes aos macrolídeos, uma classe de antibióticos usada para tratar muitas DSTs – embora nenhum tenha mostrado resistência ao tratamento mais comum da sífilis, a benzilpenicilina benzatina. Qualquer vacina contra a sífilis precisará ser adaptada às linhagens mais comuns de T. pallidum atualmente em circulação.
O professor Nicholas Thomson, autor sênior do estudo da LSHTM e do Instituto Wellcome Sanger, disse: "Foi um grande esforço logístico reunir este estudo e não poderíamos ter feito sem nossos colaboradores internacionais. Queríamos construir o campo da genômica da sífilis e esses dados fornecem uma base sólida para pesquisas futuras. Combinada com a capacidade recente de cultivar T. pallidum no laboratório, agora existe uma grande variedade de atividades neste campo, o que é importante porque a sífilis está se tornando rapidamente um público urgente questão de saúde."
Fonte :
Escola de Higiene e Medicina Tropical de Londres (LSHTM)
Referência :
Beale, M.A., et al. (2021) A filogenia global das linhagens de Treponema pallidum revela a recente expansão e disseminação da sífilis contemporânea. Nature Microbiology. doi.org/10.1038/s41564-021-01000-z.
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